5/16/25 12:57 PM
Anno.Domini.144K

In Matthew 7:7-8 (AMP), Jesus tells the crowd who has gathered to hear his sermon on the mountain, “Ask and keep on asking and it will be given to you; seek and keep on seeking and you will find; knock and keep on knocking and the door will be opened to you. For everyone who keeps on asking receives, and he who keeps on seeking finds, and to him who keeps on knocking, it will be opened.”

Having for many years received visions of plagues to come, I have asked the Holy Spirit to lead me to simple natural substances, obtainable without a prescription, that ordinary people can access to help heal them from such plagues. I trust in Jesus when in John 14:26 (AMP), He told his disciples, ^“But the Helper (Comforter, Advocate, Intercessor—Counselor, Strengthener, Standby), the Holy Spirit, whom the Father will send in My name [in My place, to represent Me and act on My behalf], He will teach you all things. And He will help you remember everything that I have told you.” The Holy Spirit continues to teach me and guide me, correcting me when in error, and giving me hope and comfort not just personally, but for others in these darkening times.

During the time of the last Ebola epidemic in sub-Saharan Africa (2013-2016), many scientists sought effective treatments for this virus infection. Currently, the only FDA-approved treatments in the US involve the patented and prescription-only monoclonal antibody treatments Inmazeb and Ebanga, (specifically for the Zaire ebolavirus). Supportive care—which includes fluids, electrolytes, managing blood pressure, and medications to control infections and complications—is essential. In a full-blown epidemic of a lethal virus such as Ebola, when hospitals are overrun and lacking supplies, and when people are quarantined at home, what can be done preventatively and proactively that is practical and possible?

I am so grateful that the Holy Spirit drew my attention to a little-publicized, small in silico study completed by researchers at the Department of Biotechnology of Graphic Era University in Dehradun, India. In their study published in 2015, three researchers developed a list of 50 known bioactive components from high altitude medicinal plants and docked them with the specific protein binding sites of five of the deadliest viruses known to humankind: Junin, Hanta, Dengue, Marburg, and Ebola. The researchers used the iGEMDOCK software to identify the bioactive compounds with the highest binding energy against binding sites.

The study is not easily found (not on PubMed), and I had to do some digging, but the research article “In silico screening of phytoactive components against Junin, Hanta, Dengue, Marburg and Ebola Viruses” can be found online at the Journal of Chemical and Pharmaceutical Research, 2015, 7(3):209-224 , ISSN : 0975-7384. (www.jocpr.com). It is somewhat buried in the archives, but be diligent and you will find it. The article’s diction is a little stilted, but scientists are not known for their prose.

Coming from a long tradition of Ayurvedic medicine in India, the researchers chose mostly plant-based compounds available without a prescription. The bioactive compounds tested in the study include: Caffeine, Eugenol, Gallic acid, Skimmianine, Bergapten, Chromone, Esculetin, Coumarin, Indole-3-carbinol, Palmatine, Malvidin, Pterostilbene, d-Limonene, Citral, Geraniol, Capsaicin, Allicin, Berlambine, Flavylium, Sulforaphane, Delphinidin chloride, Berberine chloride, Glutathione, Anthraquinone, Phytol, Quercetin, Damnacanthal, Ellagic acid, Strophanthidin, Andrographolide, Petunidin, beta-Sitosterol, Cedrol, Betulin, Ursolic acid, Lupeol, Docosahexaenoic acid (DHA), Methyl linoleate, 3,5-dihydroxy-6-methyl-2H-pyran-4(3H)-one, Bergaptol, Palmitic acid, Dehydrocostus lactone, Phytosterol, Oleic acid, Squalene, Docosanol, Costunolide, Marmin, and 1-(3-Hydroxypropyl)-2-pyrrolidone.

Here is a summary of the study’s most relevant findings:

Top 15 (out of 50) Results of Docking Between Different Ligands and Targeted Protein in the Form of Total Binding Energy for EBOLA (a filovirus):

Top 15 (out of 50) Results of Docking Between Different Ligands and Targeted Protein in the Form of Total Binding Energy for MARBURG VIRUS (a filovirus):

Top 15 (out of 50) Results of Docking Between Different Ligands and Targeted Protein in the Form of Total Binding Energy for HANTA VIRUS (a bunyavirus):

Top 15 (out of 50) Results of Docking Between Different Ligands and Targeted Protein in the Form of Total Binding Energy for DENGUE (a flavivirus):

Top 15 (out of 50) Results of Docking Between Different Ligands and Targeted Protein in the Form of Total Binding Energy for JUNIN VIRUS (an arenavirus):

Note that several of the same compounds appear high on the list for at least three if not all five of the viruses. Here are the compounds, in alphabetical order:

·      Andrographolide: found in Andrographis paniculata

·      Berberine: a natural compound found in several plants, including multiple barberry species, goldenseal, and Oregon grape, that has been used in traditional medicine for centuries.

·      Berlambine/oxyberberine: from Berberis aristate (India barberry) and many other barberry species, Chinese goldthread, Japanese goldthread, and several species of meadow rue.

·      Betulin: a natural triterpene found primarily in the bark of birch trees. It’s known for its potential anti-inflammatory, antiviral, and anticancer properties, and is also a precursor to betulinic acid, which has shown promise in treating HIV, malaria, and inflammation, according to the National Institutes of Health (NIH). Betulinic acid is also found in several foods and plants, such as sour jujube fruits, papaya, and persimmon. Betulinic acid exhibits low toxicity and a wide range of anticancer activities.

·      Delphinidin: an anthocyanidin present in pomegranates, berries, grapes, beets and eggplant. Delphinidin derivatives are mostly found in food sources such as bilberry (Vaccinium myrtillus), elderberry (Sambucus nigra), jamun (Syzygium cumini), blackcurrant (Ribes nigrum). The food source with by far the highest concentration of delphinidum is the maqui berry, also known as the Chilean wineberry (Aristotelia chilensis).

·      Glutathione: a naturally occurring compound, often called the “master antioxidant,” produced in the body from three amino acids: cysteine, glutamic acid, and glycine. It plays a crucial role in many cellular processes, including detoxification, antioxidant defense, and protein synthesis. Glutathione is abundant in various tissues, particularly the liver, and is essential for protecting cells from damage caused by free radicals and other harmful substances.

·      Malvidin: Malvidin is an O-methylated anthocyanidin, the 3′,5′-methoxy derivative of delphinidin. It is responsible primarily for the color of red wine, Vitis vinifera being one of its sources. It is also present in other berries, such as blueberries (Vaccinium corymbosum) or the saskatoon berries (Amelanchier alnifolia). Malvidin is a potent antioxidant and anti-inflammatory agent. It can scavenge free radicals and help modulate inflammatory cytokine signaling.

·      Marmin: a coumarin, that can be isolated from the immature bark of the Bengal quince/Bael (Aegle marmelos Correa). It is also found in the peel and flowers of the pomelo (Citrus maxima/Citrus grandis). Citrus maxima (Burm.) Merr (CMBM) is a traditional digestive tea in China. Marmin is also found in shangjuan/Ichang lemon Citrus wilsonii, the pomelo-mandarin hybrid hassaku orange (Citrus Hassaku), and amanatsu (Citrus natsudaidai), yellow citron (Citrus medica (etrog)), sour orange (Citrus x aurantium), and sweet orange (Citrus sinensis).

·      Palmatine: one of the primary protoberberine alkaloids, is commonly found in plants that yield berberine, such as Indian barberry (Berberis Aristata) and guduchi/giloy (Tinospora cordifolia), along with sources like Chinese goldthread (Coptis chinensis) and several other traditional Chinese medicinal herbs.

·      Petunidin: Like malvidin, petunidin is derived from delphinidin and is an O-methylated anthocyanidin of the 3-hydroxy type. It is a natural organic compound, a dark-red or purple water-soluble pigment found in many red berries including chokeberries (Aronia sp), Saskatoon berries (Amelanchier alnifolia), strawberries (Fragaria x ananassa), or different species of grape (for instance Vitis vinifera, or muscadine, Vitis rotundifolia). Petunidin is also found in jamun/Java plum (Syzygium cumini).

·      Quercetin: a plant flavonoid known for its anti-inflammatory and antiviral properties. It also functions as a zinc ionophore, aiding in the transport of zinc into cells where it can inhibit viral replication. Quercetin is found in a wide range of edible plants, but its highest content is in hot wax raw yellow peppers, ancho chilies, hot green raw chili peppers, raw lingonberries, raw red onions, boiled onions, and cranberries. Quercetin is also sourced from Sophora japonica.

·      Squalene: a naturally occurring oil, a polyunsaturated hydrocarbon, found in both animal tissues (shark liver oil) and plant sources (olive oil, amaranth oil). It’s a key component of sebum in humans, contributing to skin lubrication and protection. Squalene is also a precursor in the biosynthesis of cholesterol and other steroidal hormones.

I trust some of this data will be helpful to all disciples, not just those in the health professions. Many of us who visit and post on this site prayerfully seek guidance on how to prepare ourselves and our families for the time of the plagues. Knowledge of God’s natural remedies can help us care for our neighbors and those who God sends to us in new ways. With God’s help, we can restore bodies as we ready souls for God’s kingdom.

Scripture:

Mark 5:25-34 (AMPC)

²⁵ And there was a woman who had had a flow of blood for twelve years,

²⁶ And who had endured much suffering under [the hands of] many physicians and had spent all that she had, and was no better but instead grew worse.

²⁷ She had heard the reports concerning Jesus, and she came up behind Him in the throng and touched His garment,

²⁸ For she kept saying, If I only touch His garments, I shall be restored to health.

²⁹ And immediately her flow of blood was dried up at the source, and [suddenly] she felt in her body that she was healed of her [distressing] ailment.

³⁰ And Jesus, recognizing in Himself that the power proceeding from Him had gone forth, turned around immediately in the crowd and said, Who touched My clothes?

³¹ And the disciples kept saying to Him, You see the crowd pressing hard around You from all sides, and You ask, Who touched Me?

³² Still He kept looking around to see her who had done it.

³³ But the woman, knowing what had been done for her, though alarmed and frightened and trembling, fell down before Him and told Him the whole truth.

³⁴ And He said to her, Daughter, your faith (your trust and confidence in Me, springing from faith in God) has restored you to health. Go in (into) peace and be continually healed and freed from your [distressing bodily] disease.

Acts 3:2-8 (AMPC)

3 Now Peter and John were going up to the temple at the hour of prayer, the ninth hour (three o’clock in the afternoon),

² [When] a certain man crippled from his birth was being carried along, who was laid each day at that gate of the temple [which is] called Beautiful, so that he might beg for charitable gifts from those who entered the temple.

³ So when he saw Peter and John about to go into the temple, he asked them to give him a gift.

⁴ And Peter directed his gaze intently at him, and so did John, and said, Look at us!

⁵ And [the man] paid attention to them, expecting that he was going to get something from them.

⁶ But Peter said, Silver and gold (money) I do not have; but what I do have, that I give to you: in [the use of] the name of Jesus Christ of Nazareth, walk!

⁷ Then he took hold of the man’s right hand with a firm grip and raised him up. And at once his feet and ankle bones became strong and steady,