A few weeks ago, the Holy Spirit led me to click on a video that appeared in my YouTube feed. The video, titled “100% death rate SARS virus” and posted by Dr. John Campbell of the UK, draws attention to an unpublished Chinese scientific paper draft posted in 2024 that documents how the SARS-CoV-2-related pangolin coronavirus GX_P2V can cause 100% mortality in human ACE2-transgenic mice, potentially attributable to late-stage brain infection. These transgenic mice (genetically modified to include human DNA) contained human ACE2 receptors throughout their bodies as humans do. The paper is titled “Lethal Infection of Human ACE2-Transgenic Mice Caused by SARS-CoV-2- 2 related Pangolin Coronavirus GX_P2V(short_3UTR)”.

The paper’s authors:

• Beijing Advanced Innovation Center, Beijing University of Chemical Technology
• The Fifth Medical Center of PLA General Hospital, Beijing, China.
• Medical School, Nanjing University, China (including a doctor trained by the Chinese military, Yigang Tong)
• The stated purpose of the study: Assessed virus pathogenicity

Risk to Humans: 100% IFR underscores a spillover risk of GX_P2V into humans, and provides a unique model for understanding the pathogenic mechanisms of SARS-CoV-2-related viruses.

Details from the paper:

“GX_P2V isolate was actually a cell culture-adapted mutant. In this study, we cloned this mutant. This is not a wild type virus. It is possible that GX_P2V C7 has undergone a virulence-enhancing mutation. GX_P2V is capable of rapid mutation rates. High viral loads detected in both lung and brain tissues. Surprisingly, all the mice that were infected with the live virus succumbed to the infection within 7-8 days post-inoculation. Resulted in 100% mortality in the hACE2 mice.”

Clinical features:

• Weight loss, Piloerection, hunched posture, sluggish movements, and their eyes turned white.
• Significant amounts of viral RNA in the brain, lung, turbinate, eye, trachea, reducing with time.
• Infection did not lead to significant inflammatory reactions or cytokine storm.
• Brain with high viral counts increasing during infection.

ACE2 receptors are found in the human brain:

• Brainstem (especially areas regulating breathing and cardiovascular control).
• Hypothalamus.
• Substantia nigra.
• Cortex (low levels).
• Endothelial cells lining cerebral blood vessels.
• Some neurons and glial cells.
• The choroid plexus.

Apparently, the cloned mutated coronavirus GX_P2V impacted the hACE2 receptors in the mice’s lungs first. But just as the mice’s lungs began to heal, by the 5^th day, the viral infection had spread to the hACE2 receptors in the mice’s brains. Because of brain infection, death of all mice with human ACE2 receptors, without exception, followed by the 7-8^th day.

Here is the link to the video:

youtube.com/watch?v=Npf-B5Av7aQ

Here is the link to the Chinese study:

https://www.biorxiv.org/content/10.1101/2024.01.03.574008v1.full.pdf

Dear Readers: Prepare to shield your ACE2 receptors! That means stock up on low dose nicotine patches, Ivermectin, and Lobelia. Below is a list of other natural ACE2 inhibitors:

NATURAL ACE2 INHIBITORS

Natural ACE2 inhibitors, often studied for blocking SARS-CoV-2 viral entry, include plant-derived polyphenols, flavonoids, and terpenoids. Key compounds like quercetin, hesperidin, baicalin, and tannic acid have demonstrated the ability to inhibit the interaction between the SARS-CoV-2 spike protein and human ACE2 receptors in studies.

Top Natural ACE2 Inhibitors & Compounds

• Flavonoids: Quercetin, Apigenin, Kaempferol, Baicalin, Rutin, Hesperidin, and Neohesperidin.
• Phenolic Acids/Tannins: Tannic acid, Punicalagin, Oligomeric Proanthocyanidins (OPCs), and Salvianolic acids (A, B, C).
• Terpenoids/Other: Oleanolic acid, Ursolic acid, Withanone (from Withania somnifera also known as Ashwagandha), and Ginsenoside Rg3.
• Plant Sources: Citrus fruits (hesperidin, naringenin), Reynoutria multiflora also known as Polygonum multiflorum, He Shou Wu, or Fo-ti (emodin), Tinospora cordifolia also known as Amrita and Guduchi (tinocordiside), and Grape Seed Extract (rich in OPCs).

Mechanism of Action
These compounds act by binding to the ACE2 receptor or the spike protein’s receptor-binding domain (RBD), essentially masking them to prevent viral docking. Some, like citronellol and limonene, may downregulate ACE2 expression in cells.

Key Considerations

• Study Types: Many of these findings are based on in silico (computer modeling) and in vitro (cell culture) studies. Further clinical trials are needed to confirm efficacy in humans.
• Synergy: Combinations like zinc, ascorbic acid (Vitamin C), and theaflavin (black tea) have shown enhanced inhibitory effects on ACE2.
• Safety: While natural, these compounds should be used with caution, particularly as some pharmaceuticals that inhibit ACE2 can also increase its expression in tissues.

Thank you, Lord God, for your loving guidance as you watch over us and our health. We glorify Your Holy Name. Alleluia!

Scripture:

• Psalm 91:3-10 (NIV): “Surely he will save you from the fowler’s snare and from the deadly pestilence… you will not fear the terror of the night… nor the plague that destroys at midday… no evil shall be allowed to befall you, no plague come near your tent”.
• 2 Chronicles 7:13-14 (NIV): “When I shut up the heavens so that there is no rain, or command locusts to devour the land or send a plague among my people, if my people… humble themselves and pray and seek my face and turn from their wicked ways, then I will hear from heaven, and I will forgive their sin and will heal their land”.